Disorders in the Functional State of the Central Nervous System, Intestinal Peristalsis and Microbiocenosis in Experimental Barbiturate Poisoning

Following a single administration of sodium thiopental in high doses (85 mg/kg intraperitoneally), the animals demonstrated absence or weakening reflexes at levels spinal cord, medulla oblongata, bridge and midbrain cerebral cortex over period one day. Other signs included pronounced hypothermia, decrease respiratory rate violation its rhythm, distinct tendency to bradycardia. On days 1-3 after thiopental, restoration rate, heart body temperature, functional state central nervous system various was observed, with exception cortex. In long term, following for up 21 days, depression level cortex, coordinated propulsive peristalsis small intestine intestinal microbiocenosis were detected. Hence, experimentally simulated barbiturate poisoning, not only is suppression functions but also significant prolonged restructuring gastrointestinal tract.